FIBRINOGEN AND PLASMA VISCOSITY IN TYPE 2 DIABETIC PATIENTS

Authors

  • Μ. ΠΑΠΑΪΩΑΚΕΙΜ
  • Δ. ΧΡΗΣΤΑΚΙΔΗΣ
  • Ε. ΜΑΛΤΕΖΟΣ
  • Ν. ΓΚΟΤΣΗΣ

Abstract

Το evaluate the influence of the better control of blood glucose concentration on the plasma viscosity and the concentration of fibrinogen, we have checked HbA 1c in 100 patients with diabetes mellitus type II and we correlated it with the level of fibrinogen and plasma viscosity. Ιn the patients whose HbA 1c was more than 10,2%, plasma viscosity was 1,90±0,19 cP and in those with less than 10,2% was 1,82±0,12 cP. The difference was significant (p=0.009). The patients with HbA 1c more than 8% had higher plasma fibrinogen also (286±51 and 258±58 mg% respectively, p=0,012). We conclude that the better control of diabetes mellitus results in lower plasma viscosity and fibrinogen, which in turn could possibly help in the prevention of the vascular complications in diabetic patients.

References

Kannel WB. Lipids, diabetes and coronary heart disease: insights from the Framinham Study. Am Heart J 1985; 110:1100-7.

Kiesewetter Η, Jung F, Kotitchke G et al; Prevalence, risk factors and

rheological profile of arterial vascular disease; first results of the Aachen study. Folia Haematol (Leipz); 1988; 115 (4);587-93.

Leiper JM; Lowe GD; Anderson J et al; Effects of diabetic control and

biosynthetic human insulin on blood rheology in established diabetics. Diabetes Res; 1984; 1(1); 27:30.

Stone MC; Thorp JM: Plasma fibrinogen, a major coronary risk factor.

Journal of the Royal College of Practitioners; 1985; 565-9.

Welin L, Svardsudd Κ, Wilhelmsen L, et al: Analysis of risk factors for

stroke in a cohort of men born in 1913. NEJM 1987; 317(9); 251-6.

Fibrinogcn as a risk factor for stroke and myocardial infarction. NEJM 1984; 311; 501-5.

Poon PY , Dornan TL, Orde-Peckar C et al: Blood viscosity, glycaemic control and retinopathy in insulin -depentcnt diabetes. Clin Sci; 1982; 63(2); 211-6.

Melli Μ, Poggi Μ, Codeluppi L, et al: Blood viscosity and erythrocyte

deformability in diabetic retinopathy. Ric Clin Lab 1983; 13 Suppl 3(6); 371-4.

Reid HL, Obi GO, Oli JM: Reduccd erythrocyte deformability and

hyperfibrinogenemia in Nigerian diabetics with hemoglobin genotype

HbAA. Acta Diabetol Lat 1984; 21(2); 105-14.

Breddin HK, Krzywanek HJ, Althoff Ρ et al: PARD: Platelet aggregation as a risk factor in diabetics: results of a prospective study. Horm Metab Res Suppl 1985; 15(4); 63-8.

Schmechel Η, Beikufner Ρ, Panzram G: Longitudinal studies on the prognostic significance of plasma fibrinogen in diabetes mellitus. Ζ Gesamte Inn Med 1984; 39(18); 453-57.

Schmitz Α, Ingerslev J: Haemostatic measures in type 2 diabetic patients with microalbuminuria. Diabetic Med 1990; 7(6); 521-5.

Mercuri Μ, Orecchini G, Susta Α et al: Correlation between hemorheologic parameters and carotid atherosclerosis in stroke. Angiology 1989; 40(4 pt 1); 283- 6.

Παπαϊωακείμ. Μ: Το ιξώδες του πλάσματος και του ορού ως γενικός διαγνωστικός δείκτης. Διδακτορική Διατριβή. Αλεξανδρούπολη 1990.

Cella Α, Bianchi Ε, Reali GL, et al: Eνaluation of various hemorheologic parameters in diabetes mellitus. Boll Soc Ital Biol Sper, 1990; 66(4), 335-42.

Νeri Serneri GG, Galanti G, Paoli G: The physiopathological basis for

hemorrheological changes in diabetes. Ric Clin Lab; 1983; 13 Suppl 3(6); 149- 57.

Larsen ML, Horder Μ, Mogensen EF: Effect of long-term monitoring of

glycosylated hemoglobin levels in insulin-depentent diabetes mellitus. NEJM 1990; 323: 1021 -5.