ΤΗΕ INTRODUCTION OF ΑΝ ALTERNATIVE THERAPEUTIC PLAN IN THE MANAGEMENT OF LUNG CANCER
Abstract
Lung Cancer being still the most common visceral malignancy and accounting fo roughly one third of all cancer deaths, is associated with an overall 5-year surνival still below 10% despite all therapeutic attempts. This study presents the common as well as different biologic characteristics of the main types of Lung Cancer, namely squamous cell, adenocarcinoma, small and large cell lung cancer. The current tlιerapeutic classification into Small Cell Lung Cancer (SCLC) and Non Small Cell Lung Cancer (NSCLC) becomes obsolete. An alternative therapeutic classification is proposed where lung cancer treatment planning is based on further characteristics than anatomic extent and gross cell type. This classification is based on proliferation parameters and biologic behaviour of each and every type of Lung Cancer. Thus, the proposed classification is discussed in order to replace the current and largely insufficient one.References
Manolakis G.: Lectures in Clinical Oncology, Ch. Β: Lung Cancer, Iniv. Press, Medical University of Southern Africa (MEDUNSA) 41-48, 1993.
Casciato D.A., Lowitz Β.Β.: Manual of Bedside Oncology, Little Brown Co., 1985.
Skeel R.: Manual of Cancer Chemotherapy, Little Brown Co., 1984.
Cancer Registry: South African Cancer Incidence and Documentation, 1987.
Spiro S.G.: Lung Cancer - Presentation and Treatment. Med. Int. 3798-3805, 1991.
Beki Diagnostics AB: TPS, ELISA Tumour Proliferation Assay, Broma, Sweden, 1992.
Van Der Merwe C.F.: Prostaglandins, Leukotrienes & Disease, Univ. Press, Medical University of Southern Africa (MEDUNSA), 1994.
Robbins S.L., Cotran R.S., Kumar V.: Pathologic Basis of Disease, 3rd ed. W.B. Saunders 1984.
Jersky J.: Tumour Markers, Understanding Oncology 4, 33-34, 1990.
Sandoz-Triangle: Biology of Cancer 30, 3-4, 1991.
Κinsella T.J., Gould Μ.Ν.: Keynote Address: Integration of Cytostatic Agents and Radiation Therapy: Α Different Approach to "Proliferating human Tumours", Int. J. Rad. Oncol. Phys. 20, 295-302, 1991.
Souhami R.: Lung Cancer. Βr. Med. J. 304, 1298-1301, 1992.
Holland J., Frei Ε., Bast R. et al: Cancer Medicine, 3rd ed., 1993.
De Vita V., Hellman S., Rosenberg S.: Cancer - Principles & Practise of Oncology 4th ed., 1993.
