FLUCTUATIONS OF PLASMA VISCOSITY VALUES DURING THE ICTERIC STAGE OF THE ACUTE VIRAL HEPATITIS
Abstract
We investigated whether fluctuations of plasma viscosity values correlate with the course of the acute viral hepatitis during the icteric stage. We studied 91 cases of acute viral hepatitis, divided intο two distinct groups. The first group, comprised 53 moderately severe cases with an uneventful course [exacerbation followed by clinical and laboratory (ALT, bilirubin) improvement]. The second group comprised 38 cases with protracted illness, and fluctuations of clinical and laboratory findings . Measurements were carried out weekly with a semiautomatic viscomiter. Viscosity values in the first group showed an increase, followed by decrease or decreased steadily from the begining. In the second group, fluctuation(s) were observed before tbe final normalization. In both groups the plasma viscosity fluctuations values reflected the laboratory and clinical findings. In conclusion, the fluctuations of viscosity values, depenting mainly from the values of acute phase proteins (fibrinogen, globulins), follow closely the course of the acute viral hepatitis expressing the synthetic ability of the liver. Factors such as the quantity immune response and perhaps cholestasis influence plasma viscosity values.References
Koj Α, Gordon Η. Tbe Acute Phase Response to Injury and Infection. Amsterdam 1985: Elsevier.
Kushner I. Tbe Acute Phase Response: Απ Overview. Methods in Enzymology 1988; 163:373-83.
Kushner I. The Phenomenon of the Acute Phase Response. Αnn NY Acad Sci 1982;389:39-45
Kushner I. The Acute Phase Response: Αn Overview. Meth Enzymol 1988; 35:373-83.
Kushner J, Feldmann G. Control of tbe acute phase response. Demostration of C reactive protein synthesis and secretion by hepatocyte during acute inflamation in the rabbit. J Exp Med 1978; 148:466-477.
Harkness J. The viscosity of human plasma; its measurement in health and disease. Biorheology 1971;8:171- 93.
International Committtee for Standardization in Haematology (Expert
Panel οn Blood Rheology). Guidelines οn selection of laboratory tests for monitoring the acute phase response. J. Clin. Pathol. 1988;41: 1203-12.
Γλαρός Δ. Οι μεταβολές του ιξώδους του πλάσματος και του ορού κατά τη διάρκεια της οξείας ιογενούς ηπατίτιδας. Διδακτορική Διατριβή. Αλεξανδρούπολη: Δημοκρίτειο Πανεπιστήμιο Θράκης, Ιατρική Σχολή, έτος 1990-91.
Γλαρός Δ, Σταυράτη Αλεξ, Καραγκούνης Κ, Σιδηρόπουλος Λ, Κολοκοτρώνη Δεσπ, Παπαχρήστου Α. Ανοσοηλεκτροφορητική μελέτη ασθενών με οξεία ιογενή ηπατίτιδα. Πρακτικά 8ου Βορειοελλαδικού Ιατρικού Συνεδρίου Θεσσαλονίκη 20-22 Μαΐου 1993:657-661
Sherlock S. Diseases of the Liver and Biliary System. 8th ed: Blackwell Scientific Publications, 1989:a 304-7,b 29-30.
Seplowitz ΑΗ, Shu Chien, Smith FR. Effects of Lipoproteins on Plasma Viscosity. Atherosclerosis 1981, 38:89-95.
Leonard Η, Arntz HR, Klemens UH. Studies of plasma viscosity in primary hyperlipopidemia. Atherosclerosis 1977; 28:29.
Παπαειωακείμ Μ. Το ιξώδες του πλάσματος και του ορού ως διαγνωστικός δείκτης. Διδακτορική Διατριβή Αλεξανδρούπολη: Δ.Π.Θ. Ιατρική Σχολή 1990.
